Anti-HLA-DRA Aptamer SELEX Service(Cat#: CTApt-796)

This is an aptamer development services to screening aptamers binds to the HLA-DRA with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target HLA-DRA
Alternative Names Major Histocompatibility Complex, Class II, DR Alpha; HLA Class II Histocompatibility Antigen, DR Alpha Chain; MHC Class II Antigen DRA; HLA-DRA1; Histocompatibility Antigen HLA-DR Alpha; HLA-DRA
Gene ID 3122
UniProt ID P01903
Target Overview HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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