Anti-Human α6β4 integrin Aptamer(Cat#: CTMM-0124-TT50)
This product is an aptamer which binds to the Human α6β4 integrin with an affinity of 50-200 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
α6β4 integrin |
| Alternative Names |
ITGA6; Integrin Subunit Alpha 6; VLA-6; ITGA6A; ITGA6B; CD49 Antigen-Like Family Member F; Very Late Activation Protein 6; Integrin, Alpha 6; Integrin Alpha-6; CD49f; Integrin Alpha6B; CD49f Antigen; CD49F; JEB6
ITGB4; Integrin Subunit Beta 4; CD104; Integrin Beta-4; CD104 Antigen; GP150; Integrin, Beta 4; JEB5A; JEB5B |
| Gene ID |
3655; 3691 |
| UniProt ID |
P23229; P16144 |
| Target Overview |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
50-200 nM |
| Binding Conditions/Buffer |
PBS, 3 mmol/l MgCl₂, 1 mmol/l CaCl₂, 1 mg/ml BSA and 1 mg/ml salmon sperm DNA |
| GC Content |
50.65% |
| Molecular Weight |
23524.26 g/mole |
| nmoles/OD260 |
1.43 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
