Anti-Human BRAF V600E Aptamer(Cat#: CTMM-0124-RJ12)
This product is an aptamer which binds to Human BRAF V600E with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BRAF V600E |
| Alternative Names |
B-Raf Proto-Oncogene, Serine/Threonine Kinase; BRAF1; BRAF-1; V-Raf Mouse Sarcoma Viral Oncogene Homolog B1; V-Raf Mouse Sarcoma Viral Oncogene Homolog B; Serine/Threonine-Protein Kinase B-Raf; Proto-Oncogene B-Raf; RAFB1; B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94); Mouse Sarcoma Viral (V-Raf) Oncogene Homolog B1; B-Raf Serine/Threonine-Protein; 94 KDa B-Raf Protein; EC 2.7.11.1; B-RAF1; B-Raf; NS7; P94; BRAF |
| Gene ID |
673 |
| UniProt ID |
P15056 |
| Target Overview |
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
PBS with 4.5 g L−1 glucose, 0.1 mg mL−1 salmon sperm DNA, 1 mg mL−1 BSA and 1 mM MgCl2 |
| GC Content |
53.19% |
| Molecular Weight |
13937.1 g/mole |
| nmoles/OD260 |
2.185 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
