Anti-Human Factor IX Aptamer(Cat#: CTMM-0124-TT39)
This product is an aptamer which binds to the Human Factor IX with an affinity of 200-1000 pM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
F9 |
| Alternative Names |
Coagulation Factor IX; FIX; Plasma Thromboplastic Component; Plasma Thromboplastin Component; Christmas Factor; PTC; Christmas Disease; Hemophilia B; Factor IX F9; Factor IX; Factor 9; F9 P22; THPH8; HEMB; P19 |
| Gene ID |
2158 |
| UniProt ID |
P00740 |
| Target Overview |
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. |
| Chemical Modification |
2'-F cytidine triphosphate and uridine triphosphate |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
200-1000 pM |
| Binding Conditions/Buffer |
20 mM HEPES, 50 mM NaCl, 2 mM CaCl₂, and 0.01% BSA, pH 7.4 |
| GC Content |
52.25% |
| Molecular Weight |
11200.46 g/mole |
| nmoles/OD260 |
3.01 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
