Anti-Human FGFR1 Aptamer(Cat#: CTMM-0124-TT43)

This product is an aptamer which binds to the Human FGFR1 with an affinity of 1-50 μM.

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Summary

Specifications
Target Category Protein
Target FGFR1
Alternative Names Fibroblast Growth Factor Receptor 1; BFGFR; CEK; FLG; N-SAM; CD331; FLT2; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; BFGF-R-1; FGFR-1; FGFBR; FLT-2; HBGFR; KAL2; Heparin-Binding Growth Factor Receptor; FMS-Like Tyrosine Kinase 2; Hydroxyaryl-Protein Kinase; Fms-Like Tyrosine Kinase 2; FGFR1/PLAG1 Fusion; Pfeiffer Syndrome; CD331 Antigen; HRTFDS; N-Sam; ECCL; HH2; OGD
Gene ID 2260
UniProt ID P11362
Target Overview The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Type DNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 1-50 μM
Binding Conditions/Buffer 137 mM Na⁺ and 5 mM Mg²⁺
GC Content 60.61%
Molecular Weight 20572.35 g/mole
nmoles/OD260 1.57
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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