Anti-Human IL1A Aptamer(Cat#: CTMM-0124-RJ31)

This product is an aptamer which binds to Human IL1A with an affinity of 1-50 nM.

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5’ Modification
 
3’ Modification
 
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Summary

Specifications
Target Category Protein
Target IL1A
Alternative Names Interleukin 1 Alpha; IL1F1; Hematopoietin-1; IL1-ALPHA; IL-1A; Pro-Interleukin-1-Alpha; Preinterleukin 1 Alpha; Interleukin-1 Alpha; IL-1 Alpha; IL1; IL1A
Gene ID 3552
UniProt ID P01583
Target Overview The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Chemical Modification 2-naphthylmethyl substitutions at the 5-position of deoxyuridine (2Nap-dU)
Type DNA
Species Reactivity Human
Length <50 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer 40 mM HEPES, 102 mM NaCl, 5 mM KCl, 5 mM MgCl2, 0.01% Tween-20, pH 7.5
GC Content 45.83%
Molecular Weight 6763.3 g/mole
nmoles/OD260 3.975
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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