Anti-Human MET Aptamer(Cat#: CTMM-0124-JS12)
This product is an aptamer that binds to the Human MET protein with an affinity of 50-200 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
MET |
| Alternative Names |
MET Proto-Oncogene; Receptor Tyrosine Kinase; Hepatocyte Growth Factor Receptor; DFNB97; RCCP2; HGFR; Tyrosine-Protein Kinase Met; Scatter Factor Receptor; Proto-Oncogene C-Met; HGF/SF Receptor; HGF Receptor ; SF Receptor ; EC 2.7.10.1; Met Proto-Oncogene; EC 2.7.10; AUTS9; C-Met; DA11 |
| Gene ID |
4233 |
| UniProt ID |
P08581 |
| Target Overview |
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-200 nt |
| Affinity (Kd) |
50-200 nM |
| Binding Conditions/Buffer |
5 mM KCl in 20 mM Tris-HCl, pH 7.6 |
| GC Content |
53.49% |
| Molecular Weight |
26216.03 g/mole |
| nmoles/OD260 |
1.27 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
