Anti-Human NPPB Aptamer(Cat#: CTMM-0124-RJ15)
This product is an aptamer which binds to Human NPPB with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
NPPB |
| Alternative Names |
Natriuretic Peptide B; Brain Natriuretic Factor Prohormone; Natriuretic Peptide Precursor B; Gamma-Brain Natriuretic Peptide; Natriuretic Peptides B; PreproBNP; Iso-ANP; ProBNP; Brain Type Natriuretic Peptide; Natriuretic Protein; BNP; NPPB |
| Gene ID |
4879 |
| UniProt ID |
P16860 |
| Target Overview |
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
100 mM NaCl, 20 mM Tris-HCl, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, 0.02 % Tween 20, pH 7.6 |
| GC Content |
57.14% |
| Molecular Weight |
12369.1 g/mole |
| nmoles/OD260 |
2.377 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
