Anti-Human PCSK9 Aptamer(Cat#: CTMM-0124-LH35)
This product is an aptamer which binds to Human PCSK9 domain with an affinity of 200-1000 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
PCSK9 |
| Alternative Names |
Proprotein Convertase Subtilisin/Kexin Type 9; NARC-1; FH3; Subtilisin/Kexin-Like Protease PC9; HCHOLA3; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia, Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1; Proprotein Convertase 9; EC 3.4.21.111; EC 3.4.21.-; EC 3.4.21; LDLCQ1; FHCL3 |
| Gene ID |
255738 |
| UniProt ID |
Q8NBP7 |
| Target Overview |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
200-1000 nM |
| Binding Conditions/Buffer |
25 mM Tris-HCl, 192 mM glycine, 5 mM KH2PO4, pH=7.4 |
| GC Content |
45.56% |
| Molecular Weight |
27041.6 g/mole |
| nmoles/OD260 |
1.086 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
