Anti-Human PLAT Aptamer(Cat#: CTMM-0124-RJ56)
This product is an aptamer which binds to Human PLAT with an affinity of 200-1000 pM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
PLAT |
| Alternative Names |
Plasminogen Activator, Tissue Type; Tissue-Type Plasminogen Activator; T-Plasminogen Activator; EC 3.4.21.68; Alteplase; Reteplase; T-PA; TPA; Plasminogen Activator, Tissue; Plasminogen/Activator Kringle; EC 3.4.21; PLAT |
| Gene ID |
5327 |
| UniProt ID |
P00750 |
| Target Overview |
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
200-1000 pM |
| Binding Conditions/Buffer |
10 mM Tris-HCl, pH 8.0 |
| GC Content |
62.96% |
| Molecular Weight |
16060.4 g/mole |
| nmoles/OD260 |
1.901 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
