Anti-Human SERPINA3 Aptamer(Cat#: CTWZ-0124-WZ42)
This product is an aptamer which binds to human SERPINA3 with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
SERPINA3 |
| Alternative Names |
Serpin Family A Member 3; ACT; Alpha-1-Antichymotrypsin; AACT; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3; Cell Growth-Inhibiting Gene 24/25 Protein; Serpin A3; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3; Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 3; Growth-Inhibiting Protein 24; Growth-Inhibiting Protein 25; Alpha-1 Antichymotrypsin; GIG24; GIG25 |
| Gene ID |
12 |
| UniProt ID |
P01011 |
| Target Overview |
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
50 mM HEPES, 100 mM NaCl, 2 mM MgCl2, and 5 mM CaCl2, pH 7.4 |
| GC Content |
47.50% |
| Molecular Weight |
11439.3 g/mole |
| nmoles/OD260 |
2.443 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
