Anti-Human TFPI Aptamer(Cat#: CTMM-0124-LH39)

This product is an aptamer which binds to Human TFPI domain with an affinity of 1-50 nM.

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Lot Number

TOP
Summary

Specifications
Target Category Protein
Target TFPI
Alternative Names Tissue Factor Pathway Inhibitor; TFPI1; EPI; Extrinsic Pathway Inhibitor; LACI; TFI; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); Lipoprotein-Associated Coagulation Inhibitor; Anti-Convertin
Gene ID 7035
UniProt ID P10646
Target Overview This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Type RNA
Species Reactivity Human
Length <50 nt
Affinity (Kd) 1-50 nM
GC Content 38.24%
Molecular Weight 9778.2 g/mole
nmoles/OD260 2.695
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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