Anti-Macaca mulatta SMAD4 Aptamer(Cat#: CTWZ-0124-WZ46)

This product is an aptamer which binds to Macaca mulatta SMAD4 with an affinity of 1-50 nM.

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Summary

Specifications
Target Category Protein
Target SMAD4
Alternative Names SMAD Family Member 4; DPC4; MADH4; Mothers Against Decapentaplegic Homolog 4; Deletion Target In Pancreatic Carcinoma 4; MAD Homolog 4; MAD, Mothers Against Decapentaplegic Homolog 4 (Drosophila); Mothers Against Decapentaplegic, Drosophila, Homolog Of, 4; SMAD, Mothers Against DPP Homolog 4 (Drosophila); Deleted In Pancreatic Carcinoma Locus 4; SMAD, Mothers Against DPP Homolog 4; Mothers Against DPP Homolog 4; SMAD 4; HSMAD4; MYHRS; Smad4; JIP
Gene ID 4089
UniProt ID Q13485
Target Overview This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Type DNA
Species Reactivity Monkey
Length <50 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer 20 mM Tris-HCl, 5 mM KCl, and 500 mM NaCl, pH 7.4
GC Content 41.86%
Molecular Weight 12608.3 g/mole
nmoles/OD260 2.24
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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