Anti-MCP-1 Aptamer (CTApt-M-1055)

Specifications

Target Category	Protein
Target	CCL2
Alternative Names	MCP-1; MCP1; MCAF; HC11; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE; SMC-CF; GDCF-2; SCYA2; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je) ; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Monocyte Chemoattractant Protein-1; Chemokine (C-C Motif) Ligand 2; Monocyte Chemotactic Protein 1; Small-Inducible Cytokine A2; C-C Motif Chemokine 2; MGC9434; Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je; Monocyte Chemoattractant Protein 1; HSMCR30
Gene ID	6347
UniProt ID	P13500
Target Overview	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
Chemical Modification	2'-F-RNA
Length	60-80 nt
Affinity (Kd)	<200 pM
Binding Conditions/Buffer	Selection Buffer (110 mM NaCl, 1 mM MgCl2, 20 mM HEPES (pH 7.0), 1 mM CaCl2, 5 mM KCl, 0.001% HSA, 0.05% Tween 20)
GC Content	62.86%
Molecular Weight	22580.5 g/mole
Extinction Coefficient	670700 L/(mole·cm)
nmoles/OD260	1.49

Anti-MCP-1 Aptamer(Cat#: CTApt-M-1055)

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