Anti-Mouse IL-10R Aptamer(Cat#: CTMM-0124-RJ29)
This product is an aptamer which binds to Mouse IL-10R with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
IL-10R |
| Alternative Names |
Interleukin 10 Receptor Subunit Alpha; HIL-10R; CDW210A; CD210a; CD210; IL10R; Interleukin-10 Receptor Subunit Alpha; Interleukin-10 Receptor Subunit; Interleukin 10 Receptor, Alpha; IL-10 Receptor Subunit Alpha; IL-10R Subunit Alpha; IL-10R Subunit 1; IL-10R1; IL-10RA; Interleukin-10 Receptor Alpha Chain; CD210 Antigen; CDw210a |
| Gene ID |
3587 |
| UniProt ID |
Q13651 |
| Target Overview |
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Mouse |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
150 mmol/l NaCl, 20 mmol/l KCl, 20 mmol/l HEPES |
| GC Content |
54.88% |
| Molecular Weight |
24403.6 g/mole |
| nmoles/OD260 |
1.18 |
Customer Review
This aptamer has greatly simplified our experimental protocols
Excellent
It binds specifically to IL-10R without cross-reacting with other receptors, which has been crucial for our signaling pathway studies. The high purity and stability of the product are also noteworthy.
A versatile tool
Excellent
We chose this aptamer over antibodies due to its lower cost and comparable performance. The results have been very promising.
The quality of this aptamer is excellent
Excellent
In our comparative studies, this aptamer has outperformed several commercial antibodies. The reduced background noise and high specificity have led to more accurate and reliable data.
A trusted component in our lab
Excellent
We appreciate the high-quality control standards that go into producing this aptamer. It has significantly reduced the variability in our experiments, leading to more consistent and interpretable results. The customer support team has been very responsive and helpful.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
