Anti-Prion Protein PrP Aptamer-B2 (CTApt-M-753)

Specifications

Target Category	Protein
Target	PRNP
Alternative Names	Prion Protein ; AltPrP; CD230; PRIP ; PRP; Alternative Prion Protein ; Major Prion Protein ; CD230 Antigen ; PrP33-35C ; PrP27-30 ; P27-30 ; ASCR; CJD ; GSS ; PrP ; Gerstmann-Strausler-Scheinker Syndrome ; Creutzfeldt-Jakob Disease ; Fatal Familial Insomnia ; Prion Protein (P27-30) ; Prion-Related Protein; ALTPRP ; KURU ; PrPc
Gene ID	5621
UniProt ID	P40763
Target Overview	The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Chemical Modification	RNA
Length	40-60 nt
Affinity (Kd)	N/A
Binding Conditions/Buffer	8 mM Na2HPO4-0.87 mM KH2PO4-136 mM NaCl-112.6 mM KCl-2 mM dithiothreitol-2 mM MgCl2.
GC Content	0.53
Molecular Weight	17691.3
nmoles/OD260	1.502

Anti-Prion Protein PrP Aptamer-B2(Cat#: CTApt-M-753)