Anti-Unphosphorylated ERK2 Aptamer(Cat#: CTApt-M-1918)
This product is an aptamer which binds to the ERK2 with an affinity of <20 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ERK2 |
| Alternative Names |
Mitogen-Activated Protein Kinase 1; ERK2; P41mapk; MAPK2; PRKM1; PRKM2; ERK; Extracellular Signal-Regulated Kinase 2; Mitogen-Activated Protein Kinase 2; MAP Kinase 1; MAP Kinase 2; EC 2.7.11.2; P42-MAPK; MAPK 2; ERK-2; ERT1; Protein Tyrosine Kinase ERK2; MAP Kinase Isoform P42; EC 2.7.11; P42MAPK; MAPK 1; NS13; P38; P40; P41 |
| Gene ID |
5594 |
| UniProt ID |
P28482 |
| Target Overview |
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. |
| Chemical Modification |
RNA |
| Length |
80-100 nt |
| Affinity (Kd) |
<20 nM |
| Binding Conditions/Buffer |
34-37 °C, 10 mM Tris-HCl, pH 7.5, 10 mM MgCl2, 0.05 μg/μl tRNA |
| GC Content |
57.33 |
| Molecular Weight |
24170.59 g/mole |
| Extinction Coefficient |
732700 L/(mole·cm) |
| nmoles/OD260 |
1.36 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
