This product is an aptamer which binds to the VCAM1 with an affinity of <20 nM.
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| Target Category | Protein |
| Target | VCAM1 |
| Alternative Names | Vascular Cell Adhesion Molecule 1 ; CD106; Vascular Cell Adhesion Protein 1 ; CD106 Antigen; INCAM-100; V-CAM 1 ; VCAM-1 |
| Gene ID | 7412 |
| UniProt ID | P40763 |
| Target Overview | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. |
| Chemical Modification | 2'F-RNA |
| Length | 20-40 nt |
| Affinity (Kd) | <20 nM |
| GC Content | 0.54 |
| Molecular Weight | 11927.8 |
| nmoles/OD260 | 2.469 |