Hamster Anti-Mouse CD11c Monoclonal Antibody (CTJS-674)(Cat#: CTA-212)

This product is an unconjugated anti-Mouse CD11c Monoclonal antibody (CTJS-674) generated from the Hamster. The antibody can be used for FC.

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Specifications
Clonality Monoclonal
Clone CTJS-674
Host Animal Hamster
Isotype IgG
Immunogen Mouse spleen dendritic cells
Species Reactivity Mouse
Applications FC
Application Notes FC: 2.5 ug/10^6 cells
The optimal working dilutions should be determined by the end user.
Specificity This antibody reacts with Mouse CD11c.
Purity ≥95% as determined by SDS-PAGE
Format Lyophilized
Size 25; 100 µg
Storage 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Type Primary Antibody
Target
Target Name CD11c
Alternative Names Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c
Gene ID 3687
UniProt ID P20702
Information
Introduction CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

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