Mouse Anti-Human CD11c Monoclonal Antibody (CTJS-316)(Cat#: CTA-216)

Name: Mouse Anti-Human CD11c Monoclonal Antibody (CTJS-316)
SKU: CTA-216
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human CD11c Monoclonal antibody (CTJS-316) generated from the Mouse. The antibody can be used for WB; ELISA.

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Specifications

Clonality	Monoclonal
Clone	CTJS-316
Host Animal	Mouse
Isotype	IgG1
Immunogen	Chinese hamster ovary cell line CHO-derived recombinant human CD11c aa 20-1107
Species Reactivity	Human
Applications	WB; ELISA
Application Notes	WB: 2 µg/mL The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human CD11c.
Purity	≥95% as determined by SDS-PAGE
Format	Lyophilized
Size	25; 100 µg
Storage	12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Type	Primary Antibody

Target

Target Name	CD11c
Alternative Names	Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c
Gene ID	3687
UniProt ID	P20702

Information

Introduction

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.