Introduction of DRD2
DRD2 is encoded by the DRD2 gene. As members of the heptahelical G protein-coupled receptor superfamily, D2 receptors activate the αi subunits and then lead to inhibition of cyclic adenosine monophosphate (cAMP) synthesis. DRD2 is present mainly in the striatum of the central nervous system. DRD2 possess seven transmembrane alpha helices and uses dopamine as the preferred endogenous agonist. Meanwhile, its structure reveals a ligand binding pocket distinct from that of other structurally determined GPCRs.
|Basic Information of DRD2|
|Protein Name||D(2) dopamine receptor|
|Organism||Homo sapiens (Human)|
Function of DRD2 Membrane Protein
A number of studies show that D2 receptor signaling alters glutamate receptor function in dorsal striatal MSNs. The neuromodulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system functions through diverse signal transduction pathways. D2R is a prominent target for drug treatments in disorders where dopamine function is aberrant, such as schizophrenia. D2R signals through distinct G-protein and β-arrestin pathways and drugs that are functionally selective for these pathways could have improved therapeutic potential. It has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications.
Application of DRD2 Membrane Protein in Literature
This article indicates that D1/D2 MSNs (medium spiny neurons) in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.
This article reveals that presynaptic D2Rs in dopamine fibers of the temporal hippocampus tightly modulate long-term depression expression and play a major role in the regulation of hippocampal learning and memory.
This article reveals the mutant receptors generated provide a molecular tool set that should enable a better definition of the individual roles of G-protein and β-arrestin signaling pathways in D2R pharmacology, neurobiology, and associated pathologies.
DRD2 Preparation Options
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