DRD2 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of DRD2

Protein Name	Dopamine receptor D2
Gene Name	DRD2
Uniprot	P14416 (Human); P61168 (Mouse)
Synonym	D2R; D2DR; D(2) dopamine receptor; dopamine D2 receptor; seven transmembrane helix receptor
Background	DRD2 is encoded by the DRD2 gene. As members of the heptahelical G protein-coupled receptor superfamily, D2 receptors activate the αi subunits and then lead to inhibition of cyclic adenosine monophosphate (cAMP) synthesis. DRD2 is present mainly in the striatum of the central nervous system. DRD2 possess seven transmembrane alpha helices and uses dopamine as the preferred endogenous agonist. Meanwhile, its structure reveals a ligand binding pocket distinct from that of other structurally determined GPCRs.

DRD2 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX283	NativeExtract™ Human DRD2 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MPX4063K	MemDX™ Membrane Protein Human DRD2 Expressed in vitro E.coli expression system, Full Length	E.coli cell-free	Full length	Detergent
MP0308X	MemDX™ Membrane Protein Human DRD2 (Dopamine receptor D2) for Antibody Discovery	Wheat germ cell-free	Full length	N/A
MPX4145K	MemDX™ Membrane Protein Human DRD2 Expressed in E.coli with 10xHis tag at the N-terminus, Myc tag at the C-terminus, Partial (214-373aa)	E.coli	Partial	N/A
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Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

DRD2 Drug Discovery and Development

DRD2 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-DRD2 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

DRD2 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Viral Vector-Mediated Gene Delivery

Creative Biolabs offers viral vector-mediated gene delivery services. The principal strategy underpinning DRD2 gene therapy frequently entails the utilization of viral vectors for the precise transduction of either functional DRD2 genes or their associated regulatory elements into designated cellular populations. Compelling empirical evidence, for example, illustrates that the augmentation of DRD2 receptor expression within the nucleus accumbens of rodent models, facilitated by adenoviral vector delivery, demonstrably mitigates both alcohol consumption and cocaine self-administration. This therapeutic modality perhaps capitalizes on the inherent propensities of viral vectors for highly efficient genetic material integration into the host genome.

Gene Editing

Creative Biolabs offers gene editing services. Gene editing technologies represent a potentially transformative modality within the realm of DRD2 gene therapy, primarily due to their capacity for highly specific manipulation of the DRD2 gene locus. This sophisticated methodology permits the meticulous rectification of extant pathogenic mutations or, alternatively, the precise integration of functional DRD2 alleles directly into the host organism's genome. Consequently, this approach offers a compelling strategy for addressing disorders linked to DRD2 dysfunction, perhaps by restoring endogenous gene expression or introducing a therapeutically beneficial variant.

DRD2 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of DRD2 cell therapy. Please inquire with us for more services.

Pharmacological Inhibition Using DRD2 Antagonists

Creative Biolabs offers pharmacological inhibition research services. The judicious application of small-molecule DRD2 antagonists has served as a crucial investigative tool, primarily aimed at elucidating the therapeutic efficacy associated with DRD2 inhibition across a spectrum of oncological models. For instance, this precise pharmacological strategy has undergone rigorous evaluation within established preclinical models of both endometrial carcinoma and small cell lung cancer (SCLC). These comprehensive investigations have consistently evinced substantial antineoplastic outcomes, thereby perhaps indicating a novel therapeutic avenue for these malignancies. Consequently, the observed reduction in tumorigenic activity warrants further intricate mechanistic dissection and translational exploration.

In Vivo Models to Validate Therapeutic Efficacy

Creative Biolabs offers in vivo models development services. The rigorous substantiation of therapeutic efficacy for pharmacological interventions modulating the DRD2 necessitates the deployment of robust in vivo validation platforms. To achieve this, genetically engineered murine models, alongside patient-derived xenograft (PDX) systems, are routinely utilized. These sophisticated biological constructs, indeed, serve as instrumental tools. They perhaps provide critical insights into the therapeutic potential of DRD2-targeted agents within a complex physiological milieu, thereby advancing our understanding of their clinical applicability.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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