Carcinogen-induced mouse models enable us to study the progress of cancerous alterations, therefore to understand many of the environmental assaults people probably face and contribute to the discovery of effective treatments for resulting cancers. Creative Biolabs has established a set of carcinogen-induced mouse models for various tumor types such as hepatocellular, pulmonary, cervical, and leukocythemia to meet different requirements of our customers.
Carcinogen-induced Mouse Models
Implanted, genetically engineered and carcinogen-induced tumor models, with their specific features and difficulties for each, have laid the foundations of onco-immunology. Some mice have been genetically engineered to have pre-disposing mutations which can be activated to escape from the cellular control systems. This kind of mice will typically develop a specific tumor after exposure to a given cancer-causing agent, or the so-called carcinogen. The carcinogen could be radiation, chemical, or even physical impacts that result in mutations led to uncontrolled cell growth.
There are numerous examples of chemically-induced mice models, including digestive system cancer mice model induced by polycyclic aromatic hydrocarbons, the breast cancer models, and the oral / lung cancer induced by tobacco-specific carcinogenic compounds. Also, some chemical agents may have broad-spectrum effects in mouse models, such as cadmium and arsenic. They have been proved to induce a series of tumor in mice.
Radiation-induced models provide another way to study the mechanism of tumor. As well known, ionizing radiation would induce leukaemia in mice. Ultraviolet radiation is proposed to be an efficient method to understand skin cancer development via mice model. Mouse strain-specific characteristics of radiation effects may enhance the understanding of the process of cancer development process.
Physical agonists are likely to play a part in some certain cancers. For example, asbestos fibers may induce an effect on cells that may elicit canceration in multiple tissues, which can be studied in mice.
In addition, biological toxins (aflatoxin), bacteria (Helicobacter pylori), and tumor virus infections are also common carcinogens used to induce tumor in mice.
Advantages of Carcinogen-induced Mouse Models
Compared with transplanted tumor models or genetically engineered tumor models, carcinogen-induced models are able to simulate the tumor progress from the early stage. These may offer many leads on the general mechanisms of cellular alterations, as well as insights into tissue-specific features as well.
Why choose us?
At Creative Biolabs, we promise to offer you the most efficient mouse models for the sake of saving your precious time and ensuring the reliability of your data. If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us for more information.
Creative Biolabs is ready to provide a broad range of tumor models to assist your efficacy evaluations for novel therapies/agents:
For Research Use Only.
