Cell Line Development Service for Antibody Functional Verification

The Necessary of Effective Cell Line Development

Antibody therapies have rapidly advanced medical treatment, particularly in cancer, with over 100 commercialized drugs globally. Cellular evaluation is crucial for drug efficacy. However, conventional cells suffer from issues like low sensitivity and poor reproducibility, hindering progress in antibody therapeutic development. Additionally, the batch-to-batch variation in primary cells accelerates the disadvantages. As a result, developing an effective cell line is of great significance for antibody functional verification.

Fig. 1 The effector mechanisms of antibodies.¹

Our Cell Line Development Service for Antibody Functional Verification

Creative Biolabs widely provides a cutting-edge cell line development service for antibody functional verification. We specialize in developing custom cell lines, including functional target cell lines and effector cell lines. Furthermore, we take advantage of numerous advanced technologies to incorporate the target gene into the expression vector through transfection (lentiviral, PB vector, etc.), ensuring stable expression on the host cell surface membrane. Our skilled team of scientists is capable of assisting you in streamlining your research efforts with our stable cell line development services. Our customized resources are designed to help you achieve your research objectives efficiently and effectively.

Fig. 2 Workflow of our cell line development service.

In terms of antibody functional verification, we have developed a variety of effector reporter cell lines to meet global customers' multiple requirements for antibody functional verification. The target types preferred by customers include the following items:

In addition, we bring out a range of cell line development approaches to custom stable cell lines:

• Lentivirus transfection
• PB vector transfection

In terms of cell construction strategies, we offer a variety of promoter types, including but not limited to the following types. Customers can choose a promoter from our existing options or provide preferred promoter.

Fig. 3 Promoter system.

Advantages of Our Cell Line Development Service for Antibody Functional Verification

• Robust cell banking systems.
• A strong response signal guarantees high sensitivity.
• Broad coverage for efficient screening of diverse antibody drug effects.
• Efficient host cell transfection.
• High levels and stable expression of foreign genes.

As an industrial-leading company, Creative Biolabs excels in designing stable cell lines utilizing highly sensitive biosensors to target a diverse range of molecules. Simultaneously, we also provide well-constructed GPCR Cell Lines to aid in therapeutic compound screening.

If you are interested in our cell line development for antibody functional verification, please reach out to us with your requirements.

Reference

1. Zahavi, David, and Louis Weiner. "Monoclonal antibodies in cancer therapy." Antibodies 9.3 (2020): 34.

For Research Use Only.