Creative Biolabs has been a long-term expert in the field of antibacterial and antifungal drug discovery. Based on our extensive experience and world-leading technology platforms, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory minimum biofilm inhibitory concentration (MBIC) test service.
Bacterial biofilms are complex communities of surface-attached bacteria. Bacteria adhere to the contact surface and secrete polysaccharide matrix, fibrin, lipoprotein, etc. to form a large number of bacterial aggregated membrane-like substances. Bacterial biofilm formation is a complex process with five main stages, which include initial attachment of microorganisms, irreversible attachment, extracellular polymeric substances (EPS) production, maturation, and proliferation, as well as detachment.
Bacterial biofilms present beneficial roles in a variety of fields, such as plant protection, bioremediation, wastewater treatment, and corrosion inhibition. According to surface modification and QS signals, beneficial biofilms formation can be encouraged. However, bacterial biofilms are considered serious issues in many branches related to water, food, pharmacy, and healthcare.
Fig.1 The five main phases leading to the development and dispersal of biofilm. (Muhammad, 2020)
Minimum Biofilm Inhibitory Concentration (MBIC) is defined as the lowest concentration of the antimicrobial agent to inhibit the initial formation of biofilm. At this concentration, there was no time-dependent increase in the average number of viable cells in the biofilm. Correspondingly, minimum biofilm eradication concentration (MBEC) is the lowest concentration necessary to eradicate already formed biofilm. MBIC and MBEC have been served as a guide for the treatment of biofilm-associated infections. In general, MBICs of antimicrobials tend to be much lower than MBECs because the concentrations of antimicrobials required to prevent initial biofilm formation are much lower than those required to eradicate established biofilms. Creative Biolabs provides the time efficient and accurate MBIC assay to test antimicrobial agent efficacy against bacterial biofilm.
Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for antibacterial and antifungal drug discovery. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.
Reference
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