Creative Biolabs is a world-renowned leader in providing renal disease NHP model for a broad range of drug development projects, including acute renal failure (ARF), chronic renal failure (CRF), and renal hypertension (RH). Our scientists have accumulated remarkable experience in NHP disease model establishment as well as various pharmacodynamics/efficacy studies. In particular, we are now proud to introduce our renal hypertension NHP model to our clients around the world.
Advantages of non-human primates (NHPs)
Renal disease refers to damages/abnormal status of the kidney that can cause different levels of kidney function failures. Non-human primates (NHPs) are by far the most accurate and relevant models for human diseases in contrast to other animals since they share high similarities with human beings in physiological, behavioral and pathophysiological characteristics.
What is renal hypertension?
Renal hypertension (also known as “renovascular hypertension”) is a disease condition characterized by high blood pressure due to the kidneys' hormonal response which narrows the arteries supplying the kidneys. This hormonal axis regulates blood pressure under physiological conditions. However, in the presence of low local blood flow, the kidneys will tend to increase the blood pressure of the entire circulatory system mistakenly. This can be considered as a form of secondary hypertension of which the cause is still identifiable.
The pathogenesis of renal hypertension
In renal hypertension, the renin-angiotensin-aldosterone system (RAAS) plays a vital role. Renal hypertension can be experimentally induced by renal artery constriction that activates peripheral RAAS and sympathetic nervous system. When sympathetic activity is enhanced, the kidney will secrete a special enzyme termed renin (aka angiotensinogenase), which can convert angiotensinogen to angiotensin-I (Ang-I). Ang-I can be then converted to angiotensin-II (Ang-II), a potent vasoconstrictor that can increase blood pressure (BP). Apart from the role in vasoconstriction, Ang II also stimulates the release of aldosterone, thus resulting in increased blood volume and hypertension due to salt and water retention. Renal hypertension can be induced by various methods as follows:
RH models provided by Creative Biolabs
We can provide customized RH building service mainly based on Goldblatt method. We can conduct a full portfolio of testing measures to validate the modeling efficacy as well as evaluate the PD characteristics of certain treatment/intervention:
Creative Biolabs offers various Urogenital Disease Models you may be interested in. Please feel free to contact us for more discussions.
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