Creative Biolabs is a world-renowned leader in providing renal disease NHP model for a broad range of drug development projects, including acute renal failure (ARF), chronic renal failure (CRF), and renal hypertension (RH). Our scientists have accumulated remarkable experience in NHP disease model establishment as well as various pharmacodynamics/efficacy studies. In particular, we are now proud to introduce our renal hypertension NHP model to our clients around the world.

Advantages of non-human primates (NHPs)

Renal disease refers to damages/abnormal status of the kidney that can cause different levels of kidney function failures. Non-human primates (NHPs) are by far the most accurate and relevant models for human diseases in contrast to other animals since they share high similarities with human beings in physiological, behavioral and pathophysiological characteristics.

Renal Hypertension (RH) Model

What is renal hypertension?

Renal hypertension (also known as “renovascular hypertension”) is a disease condition characterized by high blood pressure due to the kidneys' hormonal response which narrows the arteries supplying the kidneys. This hormonal axis regulates blood pressure under physiological conditions. However, in the presence of low local blood flow, the kidneys will tend to increase the blood pressure of the entire circulatory system mistakenly. This can be considered as a form of secondary hypertension of which the cause is still identifiable.

Renal Hypertension (RH) Model

The pathogenesis of renal hypertension

In renal hypertension, the renin-angiotensin-aldosterone system (RAAS) plays a vital role. Renal hypertension can be experimentally induced by renal artery constriction that activates peripheral RAAS and sympathetic nervous system. When sympathetic activity is enhanced, the kidney will secrete a special enzyme termed renin (aka angiotensinogenase), which can convert angiotensinogen to angiotensin-I (Ang-I). Ang-I can be then converted to angiotensin-II (Ang-II), a potent vasoconstrictor that can increase blood pressure (BP). Apart from the role in vasoconstriction, Ang II also stimulates the release of aldosterone, thus resulting in increased blood volume and hypertension due to salt and water retention. Renal hypertension can be induced by various methods as follows:

  • Goldblatt method [e.g. two-kidney, one-clip hypertension (2K1C), one-kidney, one-clip hypertension (1K1C), two-kidney, two-clip hypertension (2K2C)]
  • External compression of renal parenchyma
  • Coarctation of aorta
  • Reduced renal mass
  • Glomerular sclerosis secondary to microsphere embolization

RH models provided by Creative Biolabs

We can provide customized RH building service mainly based on Goldblatt method. We can conduct a full portfolio of testing measures to validate the modeling efficacy as well as evaluate the PD characteristics of certain treatment/intervention:

  • Blood pressure
  • Complete blood count (CBC)
  • Serum biochemistries
  • Urine electrolytes
  • Biopsy
  • Histology for kidney

Creative Biolabs has extensive expertise in building a wide range of NHP disease models. In addition to the renal system, we also offer well-established disease models of neurological disease, cardiovascular and metabolic disorders, liver disease, urogenital disease, immune system disease, etc. If you can find your desired NHP model, please feel free to contact us for further discussions.



Online Inquiry

Name:
*Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.

Contact Us

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:
Europe
Heidenkampsweg 58, 20097 Hamburg, Germany
Tel: 44-207-097-1828
Email:

Follow us on:
Copyright ©2011 - 2020 Creative Biolabs.