Creative Biolabs has been long dedicated to providing super-quality urogenital disease NHP models. We are pleased to leverage our extensive expertise and advanced platform to tailor the best service and most qualified products that can satisfy every specific demand from our clients all over the world.

What is urogenital disease?

Urogenital system (also known as a genitourinary system in vertebrates) refer to the organs responsible for reproduction and urinary excretion. Although their functions are irrelevant, the structures involved are morphologically associated and often use common ducts. Generally, the major structures of the urinary system in mammals are consist of the kidneys, ureters, bladder, and urethra. The urogenital disease is thus generally referred to diseases associated with the urogenital system.

Urogenital Disease Models

Advantages of non-human primates (NHPs) models

Non-human primates (NHPs) often serve as ideal animal models for studying human disease pathogenesis and preclinical assessment of vaccines, therapeutic/diagnostic agents. NHPs present advantages over rodent models because they share high levels of genetic and physiological homology with humans.

Typical urogenital disease models provided by Creative Biolabs

Overactive bladder activity (OAB) is a clinical diagnosis based on the presence of the symptom of urinary urgency accompanied by urinary frequency and nocturia, with or without urgency urinary incontinence. Based on the predominant site of deficit, animal models of OAB can generally be divided into peripheral and central models. Creative Biolabs can provide highly tailored NHP models according to customers' demands. A full set of endpoint measurements are also available:

  • Voiding intervals on cystometrography
  • Functional bladder volume on cystometrography
  • Detrusor strip study

Urogenital Disease Models

Benign prostatic hyperplasia (BPH) is a common prostatic disorder involves non-cancerous hyperplasia of the prostate. Large, fairly discrete nodules formed in BPH will push on and narrow the urethra and increase resistance to flow of urine. Our company provides the BPH model induced majorly by androgen. Different proliferative phases of BPH model can be obtained using this method. We further provide a variety of endpoint measurements as follows:

  • Urinary maximum flow rate
  • Urinary average flow rate
  • Post-voiding residual (PVR)
  • Maximum urinary flow volume
  • Intra-bladder pressure
  • Urination rate
  • Prostate weight
  • Prostate stiffness

Creative Biolabs has been committed to the establishment, optimization of various NHP disease models with the aim of facilitating diverse preclinical research programs. Our experienced scientists are willing to work with you step by step and tailor the best NHP model to meet every specific requirement. Additionally, our team has also built many other disease models including neurological disease, renal disease, cardiovascular and metabolic disorders, liver disease, immune disease, etc. Please feel free to contact us for further discussions.



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