Creative Biolabs has been long dedicated to providing super-quality urogenital disease NHP models. We are pleased to leverage our extensive expertise and advanced platform to tailor the best service and most qualified products that can satisfy every specific demand from our clients all over the world.
The urogenital system (also known as a genitourinary system in vertebrates) refers to the organs responsible for reproduction and urinary excretion. Although their functions are irrelevant, the structures involved are morphologically associated and often use common ducts. Generally, the major structures of the urinary system in mammals consist of the kidneys, ureters, bladder, and urethra. The urogenital disease is thus generally referred to disease associated with the urogenital system.
Non-human primates (NHPs) often serve as ideal animal models for studying human disease pathogenesis and preclinical assessment of vaccines, and therapeutic/diagnostic agents. NHPs present advantages over rodent models because they share high levels of genetic and physiological homology with humans.
Chronic renal failure (CRF) is commonly considered as the progressive loss of kidney function. CRF can be induced by surgical procedures, freezing, electric coagulation, or infusions of drugs/substances, etc.
Acute renal failure (ARF) is a rapid-onset disease characterized by the loss of the kidney's excretory function and is typically diagnosed by the accumulation of end products of nitrogen metabolism (creatinine and urea) and/or decreased urine output. Currently, ARF models can be divided into ischemic-induced models, drug-induced models (e.g. cisplatin, NSAIDs, gentamicin, and cisplatin), sepsis-induced models as well as others.
Renal hypertension (RH) is a pathological condition characterized by high blood pressure due to the kidneys' hormonal response which narrows the arteries supplying the kidneys. Renovascular hypertension can be induced by various methods, such as the Goldblatt method, external compression of renal parenchyma, coarctation of the aorta, reduced renal mass, and glomerular sclerosis secondary to microsphere embolization. We provide customized RH modeling services mainly based on the Goldblatt method.
Overactive bladder activity (OAB) is a clinical diagnosis based on the presence of the symptom of urinary urgency accompanied by urinary frequency and nocturia, with or without urgency urinary incontinence. Based on the predominant site of deficit, animal models of OAB can generally be divided into peripheral and central models. Creative Biolabs can provide highly tailored NHP models according to customers' demands. A full set of endpoint measurements are also available:
Benign prostatic hyperplasia (BPH) is a common prostatic disorder that involves non-cancerous hyperplasia of the prostate. Large, fairly discrete nodules formed in BPH will push on and narrow the urethra and increase resistance to the flow of urine. Our company provides the BPH model induced majorly by androgen. Different proliferative phases of the BPH model can be obtained using this method. We further provide a variety of endpoint measurements as follows:
Diabetic Nephropathy (DN) is one of the common microvascular complications of diabetes and one of the main causes of death. Glomerular sclerosis is the main cause of abnormal glucose metabolism in diabetes, and the urine protein content exceeds the normal level. Creative Biolabs provides the well-established and verified DN model in rhesus monkeys, and related analysis services including blood analysis, renal function evaluation, renal histopathology, immunohistochemistry, color doppler ultrasound, and angiography, mRNA expression levels analysis, immunofluorescence for eNOS, IL-1β, and MCP-1, etc.
Creative Biolabs has been committed to the establishment and optimization of various NHP disease models with the aim of facilitating diverse preclinical research programs. Our experienced scientists are willing to work with you step by step and tailor the best NHP model to meet every specific requirement. Please feel free to contact us for further discussions.
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