As a leading company in the field of the drug industry, Creative Biolabs has gained a wealth of good reputation for successfully completed numerous challenges in antifungal drug discovery. Based on our advanced technology platform and experienced scientists, we are able to offer a series of antifungal drug discovery services against tinea corporis.

What is Tinea Corporis?

Tinea Corporis, also known as ringworm, tinea circinata, and tinea glabrosa, is a superficial dermatophytosis of the arms and legs, especially on glabrous skin excluding the scalp, beard, face, hands, feet, and groin. Trichophyton rubrum is the most common cause of tinea corporis worldwide as it spreads from those who infected with tinea pedis. As the most often cause of tinea capitis, Trichophyton tonsurans is another frequent cause of tinea corporis. Microsporum canis is a causative organism of tinea corporis in children when the spread is from animals.

Besides, there are other causative dermatophytes that cause tinea corporis including:

  • Epidermophyton floccosum
  • M. audouinii
  • T. verrucosum
  • T. schoenleinii
  • T. violaceum
  • T. equinum
  • T. mentagrophytes
  • M. persicolor
  • M. gypseum
  • M. nanum

Transmission and Risks of Tinea Corporis Infection

  • Tinea corporis is often acquired by direct skin contact with an infected individual person-to-person. To a human, animal transmission is also a common cause, which including pets, horses, pigs, ferrets, and cows.
  • Tinea corporis infection is prone to be more often in children and immunocompromised individuals. A humid wet environment as excessive perspiration and clothing with poor aeration may also provide an environment where the dermatophyte organisms can thrive.

Tinea corporis infection. Fig.1 Tinea corporis infection.

Symptoms and Signs

  • Tinea corporis is typically characterized by an annular or oval erythematous plaque with a raised leading edge and scaling.
  • Another common symptom is pruritus, and pain may be felt if the involved area is macerated or secondarily infected.
  • Other classic presentations of tinea corporis include: skin surrounding the lesions may be dry and flaky, and areas of the infection will be hair loss.

Diagnosis and Prevention

  • For diagnosis, laboratory testing called KOH Test for confirmation is necessary as tinea corporis closely resembles impetigo and nummular dermatitis.
  • Keeping skin dry, avoiding contact with infectious material, and good hygiene will be helpful in preventing tinea corporis in daily life.

Treatment

Topical therapy is effective for most cases of tinea corporis, antifungals including:

  • Azoles (sulconazole, oxiconazole, miconazole, clotrimazole, econazole, and ketoconazole);
  • Allylamines (naftifine and terbinafine);
  • Benzylamine derivatives (butenafine);
  • Hydroxypyridones (ciclopirox olamine).

If extensive infections, the chronic or recurrent incidence, or immunocompromised patients with tinea corporis, it would be better to choose oral treatments. Itraconazole and terbinafine are the most frequently used antifungal medications.

Types of Dermatophytosis Studied by Creative Biolabs

As a part of our antifungal drug research, Creative Biolabs has abundant and professional experience in dermatophytosis research. Our professional scientists will work closely with our customer and provide you with high-quality, flexible, and cost-effective services. Besides tinea corporis, other types of dermatophytosis are also within our scope of service.

If you are interested in the fungal diseases we investigate, please click the links above. For more detailed information, just feel free to contact us.



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