As a leading company in the field of the drug industry, Creative Biolabs has gained a wealth of good reputation for successfully completed numerous challenges in antifungal drug discovery. Based on our advanced technology platform and experienced scientists, we are able to offer a series of antifungal drug discovery service against dermatophytosis.
What is Dermatophytosis?
Dermatophytosis is a contagious infection caused by fungi known as dermatophytes. It is also an inflammatory reaction in the host of the superficial tissues such as the epidermis, hair, and nails. Dermatophytosis often results in typical symptoms like a red, itchy, scaly rash and hair loss. Multiple areas can be affected at a given time. Dermatophytosis can spread from other animals or between people. Dermatophytosis can be caused by about 40 types of fungus typically in the genera-Microsporum, Trichophyton and Epidermophyton. Members of Microsporum and Trichophyton cause infections in both humans and animals. While, in the genera Epidermophyton, E. floccosum is the only pathogenic species known to cause dermatophytosis, and it only affects humans.
Fig.1 Types of Dermatophytosis.
Different types of dermatophytosis affect the body in different ways. Some types are mild, but some of them are serious. The common types of dermatophytosis include:
Tinea pedis, also called Athlete's foot, is a common skin infection of the feet caused by fungus. It may infect any part of the foot, but most often occurs between the toes (interdigital), with the space between the fourth and fifth digits most commonly afflicted.
Tinea unguium, also known as Onychomycosis, is a fungal infection of the nail. Typical symptoms include white or yellow nail discoloration, thickening of the nail, and separation of the nail from the nail bed. Older people are affected more frequently, and males are affected more often than females.
Tinea corporis, also called tinea circinata and tinea glabrosa, is a superficial fungal infection of the arms and legs, especially on glabrous skin. Tinea corporis usually affects exposed skins but also might be spread from other infected sites. It can be acute (sudden onset and rapid spread) or chronic (slow extension of a mild, barely inflamed, rash).
Tinea cruris, also referred to jock itch, is a fungal infection in the groin area in either sex, but more often in males. The infection results in itching or a red with flaking skin.
Tinea manuum or tinea manus, is a fungal infection of the hand. It is more aggressive than tinea pedis but similar to in look. The observed symptoms in tinea manuum patients are itching, burning, cracking, and scaling.
Tinea capitis, also known as herpes tonsurans and scalp ringworm, is a cutaneous fungal infection of the scalp. Its typical presentation is single or multiple patches of hair loss that may be accompanied by inflammation, scaling, pustules, and itching. Tinea manuum is predominantly seen in pre-pubertal children.
Tinea barbae, also called Barber's itch, is a fungal infection of the hair due to the infection around the bearded area of men. The transmission of tinea barbae is more often from animal-to-human than human-to-human.
Tinea faciei is a fungal infection of the face. It usually results in a red rash on the face, followed by patches of small, raised bumps, and the skin may peel after treatment. Tinea faciei can spread easily to any regions of skin.
Tinea versicolor, also called pityriasis versicolor, is a fungal infection of the skin. It is caused by the yeast, and predominantly in adolescents and young adults. Tinea versicolor gets worse in hot, humid climates and may disappear during cool weather.
Tinea nigra is a superficial mold infection of the stratum corneum that causes dark brown to black painless patches on the palms of the hands and the soles of the feet. Its clinical presentation is a single painless sharply demarcated brown to black macule on the palmar surface of the hand or finger or on the plantar surface of the foot or other sites.
Types of Dermatophytes
Dermatophytes are a group of fungus that commonly causes skin disease in animals and humans. Dermatophytes originate from soil-dwelling keratinophilic organisms, but only a few species still reside primarily in the niche and mostly have become adapted to people or animals. There are approximately 40 species dermatophytes, which generally are in three genera-Microsporum, Trichophyton and Epidermophyton. Both Microsporum and Trichophyton cause dermatophytosis in humans and animals. Several representative pathogenic fungi are listed as follows:
Fig.2 Three genera of dermatophytes.
Types of Fungal Diseases Studied by Creative Biolabs
Aided by top technology and professional scientists, Creative Biolabs is committed to promoting the development of global customers’ programs. In addition to Dermatophytosis, we also provide potential antifungal drug discovery services against other fungal diseases, which including but not limited to:
|Pneumocystis Pneumonia||Fungal Keratitis|
If you are interested in the fungal disease we investigate, please click the links above. For more detailed information, just feel free to contact us.
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