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Custom Oligonucleotide Modification Service


A number of oligonucleotide modifications have been identified and applied for improving the properties of nucleic acid drugs, including increasing stability, specificity, and affinity while reducing toxicity due to off-target effects. Creative Biolabs is an excellent service provider and committed to providing a full range of custom oligonucleotide modification services with high quality and low cost. Our end-to-end oligonucleotide modification services will help you optimize the nucleic acid drug properties, promoting their applications in the precise treatment of genetic diseases.

Importance of Oligonucleotide Modification in RNA Therapeutics

RNA therapeutics provides tremendous potential for the precise treatment of genetic diseases. It uses oligonucleotides targeting RNAs involved in various diseases for therapeutic efforts, with greater specificity, improved potency, and decreased toxicity. In spite of the tremendous advances of RNA therapeutics, there are also many challenges remaining. Unmodified oligonucleotides have been revealed to possess poor drug-like properties, such as unstable, easy to be degraded by nucleases, low RNA-binding affinity and so on.

Currently, a number of oligonucleotide modification and conjugation strategies have been revealed and established to improve the therapeutic effect of RNA medicines. In particular, some oligonucleotide modifications can increase stability, binding affinity, and specificity, improve RNase H cleavage specificity, cellular uptake, and subcellular trafficking, as well as reduce the immune response induced by oligonucleotides. For example, phosphorothioate (PS) modification can increase the stability of oligonucleotide, protecting them from degradation by nucleases. Locked nucleic acid (LNA) modification can increase the specificity, affinity, and half-life of oligonucleotide drugs, allowing effective delivery to tissues of interest with lower toxicity.

Nucleotide analogues used in antisense oligonucleotide drugs. Figure 1. Nucleotide analogues used in antisense oligonucleotide drugs. (Rigo, 2013)

Oligonucleotide Modification Services

Over the past decades, Creative Biolabs has accumulated extensive expertise in the field of oligonucleotide modification over the past decades. A variety of oligonucleotide modifications are available and can be introduced either during oligo synthesis, or post-synthetically to improve the nuclease stability, RNA-binding affinity and pharmacokinetic properties of oligonucleotides for therapeutic applications. According to your project’s requirement, we can tailor a personalized solution for oligonucleotide modification, aiming to maximally improve the therapeutic effect of RNA medicines. The oligonucleotide modification types we provided include but not limited to:

Features

Creative Biolabs has a wealth of expertise in enhancing the properties of RNA drugs (such as specificity, affinity, and nuclease resistance) through various oligonucleotide modifications. Our excellent expert staff provides a variety of flexible and reliable solutions of oligonucleotide modification to improve the therapeutic effect of RNA medicines. If you are interested in our services, please don’t hesitate to contact us for more details.

Reference

  1. Rigo, F.; et al. (2013). Antisense-based therapy for the treatment of spinal muscular atrophy. Journal of Cell Biology. 199(1):39-43.

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