Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe histamine receptors are a type of G protein-coupled receptors which bind histamine as their primary endogenous ligand. Histamine is a monoamine signaling molecule that functions through four G-protein-coupled histamine receptors: H1, H2, H3, and H4. Histamine mediates many of the biological activities stimulated by various immunological and non-immunological stimuli by differential expression of H1 to H4 on effector cells, including mast cells and basophils, etc. Histamine receptors are activated by the endogenous ligand histamine. There are significant species differences between histamine receptor orthologues. The H3 receptor genes in human and rat are significantly spliced variance. The potency order of histamine at histamine receptor subtypes is H3 = H4 > H2 > H1. Some agonists of the human H3 receptor show significant ligand preference.
Fig.1 Histamine receptor signaling. (Scammell, 2011)
Here show four of the histamine receptors, HRH1 to HRH4, which are four variants encoded by different genes. There are various splice variants of H3 in different species. Although all the receptors are 7-transmembrane G protein-coupled receptors, H1 and H2 are very different from H3 and H4 in their activities. H1 causes an increase in PIP2 hydrolysis. H2 stimulates gastric acid secretion. H3 mediates feedback inhibition of histamine.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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