Close

Leucine-rich Repeat-containing Protein Family

Leucine-rich repeat-containing (LRRC) protein family consists of several hundred member proteins which are characterized by two or more leucine-rich repeated motifs (LRR). The function of LRR motifs is suggested to provide a versatile framework for forming protein-protein interactions. Among LRRC proteins, LRRC52, LRRC55, LRRC38, and LRRC26 are identified as auxiliary proteins of BK (Big conductance of K+) channels, which can leftward shift GVs of Slo1 channels from several tens to 120 mV. Whereas, LRRC8A, LRRC8B, LRRC8C, LRRC8D, and LRRC8E are identified as subunits of the heteromer protein volume-regulated anion channel (VRAC) which play crucial roles in the regulation of cell size by transporting chloride ions and various organic osmolytes. Studies have shown that transmembrane LRRC proteins are expressed exclusively in the nervous system, and extracellular LRR domains can serve as protein-protein interaction motifs. Furthermore, LRRC proteins have diverse physiological functions including antibacterial reaction, maintenance of normal cardiac function, regulation of trafficking of membrane receptors and regulation of the activity of ion channels, etc.

Here, we have described in details of members of the LRRC protein family, which includes but not limited to leucine-rich repeat-containing protein 26, leucine-rich repeat-containing protein 38, and leucine-rich repeat-containing protein 52. To learn more detailed information, please click the links below.

Human LRRC Protein Family Members
LRRC26 LRRC38 LRRC52
LRRC55 LRRC8A LRRC8B
LRRC8C LRRC8D LRRC8E

With the help of our advanced Magic™ membrane protein production platform, Creative Biolabs is committed to offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us