Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsLeucine-rich repeat-containing (LRRC) protein family consists of several hundred member proteins which are characterized by two or more leucine-rich repeated motifs (LRR). The function of LRR motifs is suggested to provide a versatile framework for forming protein-protein interactions. Among LRRC proteins, LRRC52, LRRC55, LRRC38, and LRRC26 are identified as auxiliary proteins of BK (Big conductance of K+) channels, which can leftward shift GVs of Slo1 channels from several tens to 120 mV. Whereas, LRRC8A, LRRC8B, LRRC8C, LRRC8D, and LRRC8E are identified as subunits of the heteromer protein volume-regulated anion channel (VRAC) which play crucial roles in the regulation of cell size by transporting chloride ions and various organic osmolytes. Studies have shown that transmembrane LRRC proteins are expressed exclusively in the nervous system, and extracellular LRR domains can serve as protein-protein interaction motifs. Furthermore, LRRC proteins have diverse physiological functions including antibacterial reaction, maintenance of normal cardiac function, regulation of trafficking of membrane receptors and regulation of the activity of ion channels, etc.
Here, we have described in details of members of the LRRC protein family, which includes but not limited to leucine-rich repeat-containing protein 26, leucine-rich repeat-containing protein 38, and leucine-rich repeat-containing protein 52. To learn more detailed information, please click the links below.
With the help of our advanced MemDX™ membrane protein production platform, Creative Biolabs is committed to offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Furthermore, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
