Introduction of LRRC55
LRRC55, the full protein name being leucine-rich repeat-containing protein 55, is encoded by the LRRC55 gene in human. It’s expressed in the brain, lymph node and other tissues. The LRRC55 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. It is one of the auxiliary γ subunits of BK channels. It can shift gating voltages of BK channels around 50mV. It’s the only γ subunit which is expressed in the mammalian nervous system.
|Basic Information of LRRC55|
|Protein Name||Leucine-rich repeat-containing protein 55|
|Aliases||BK channel auxiliary gamma subunit LRRC55|
|Organism||Homo sapiens (Human)|
Function of LRRC55 Membrane Protein
LRRC55 (Leucine-rich repeat-containing protein 55) is a single transmembrane protein. It’s an auxiliary subunit of the large-conductance, voltage and calcium-activated potassium channel (BK alpha channel). BK channels consist of the homotetrameric pore-forming voltage and calcium-sensing α subunits (BKα), or regulatory tissue-specific auxiliary β or γ subunits. BK channel auxiliary γ (BKγ) subunits are a group of leucine-rich repeat (LRR)-containing membrane proteins, including γ1 (LRRC26), γ2 (LRRC52), γ3 (LRRC55), and γ4 (LRRC38). Also, LRRC55 can shift the gating voltages of BK channels in the absence of cytosolic calcium, and the activity is dependent on activation in the hyperpolarizing direction. These subunits show distinct expression in different human tissues, and LRRC55 is mainly expressed in the brain. In addition, LRRC55 plays an important role in MHb and cerebellum based on the function of BK channels in the brain. In addition, LRRC55 is associated with stress fracture predisposition detected by whole-exome sequencing.
Fig.1 Structural features of LRRC55 (γ3) (Li, 2015)
Application of LRRC55 Membrane Protein in Literature
This article indicates that LRRC55 plays an important role in MHb and cerebellum based on the function of BK channels in brain.
This article shows the molecular basis for differential modulation of BK channel by gamma subunits, and LRRC55 is gamma-3 subunit.
This article shows that LRRC55 can interact with BK channels to modulate their function.
This article investigates the mutated genes in stress fracture predisposition, and LRRC55 is identified by whole-exome sequencing.
This article demonstrates that LRRC55 produce a marked shift in the BK channel's voltage depending on the activation in the hyperpolarizing direction in the absence of calcium.
LRRC55 Preparation Options
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