Home > Products > BAFF & B7RP1 > Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc)  (BSCFV-018)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-BAFF specificity or anti-B7RP1 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

Specifications
Targets
BAFF & B7RP1
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Mouse
Target 2
B7RP1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE)
Targets
Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
B7RP1
Gene ID
UniProt ID
Alternative Names
ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7­related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
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