Name: Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc-scFv)
SKU: BSTF-018
Rating: 5 (1 reviews)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-BAFF scFv is fused to the N-terminus of Fc via a hinge region while another anti-B7RP1 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

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Specifications

Targets

BAFF & B7RP1

Type

scFv-Fc-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE)

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

BAFF

Gene ID

10673

UniProt ID

Q9Y275

Alternative Names

TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

Target 2

B7RP1

Gene ID

23308

UniProt ID

O75144

Alternative Names

ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-018)

Specifications

Targets

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