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Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (Fab-scFv-Fc)  (CAT#: FABVC-H239)

Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD28 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CSPG4 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma therapy.
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Specifications

Targets
CD28 & CSPG4
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma

Targets

Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
CSPG4
Gene ID
UniProt ID
Alternative Names
NG2; Neuron-glial antigen 2; Melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4; CSPG4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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