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NGF Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H344 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody NGF Human TNF Human Inquiry
T-BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody NGF Mouse TNF Mouse Inquiry
SCIGG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs NGF Human TNF Human Inquiry
SCIGG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs NGF Mouse TNF Mouse Inquiry
FVTIG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig NGF Human TNF Human Inquiry
FVTIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig NGF Mouse TNF Mouse Inquiry
BSSG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-IgG) Human scFv-IgG NGF Human TNF Human Inquiry
BSSG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-IgG) Human scFv-IgG NGF Mouse TNF Mouse Inquiry
IGLFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv NGF Human TNF Human Inquiry
IGLFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv NGF Mouse TNF Mouse Inquiry
BSGV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv NGF Mouse TNF Mouse Inquiry
BSGV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv NGF Mouse TNF Mouse Inquiry
BSDG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fv-IgG) Human Fv-IgG NGF Human TNF Human Inquiry
BSDG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fv-IgG) Human Fv-IgG NGF Mouse TNF Mouse Inquiry
BABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 NGF Human TNF Human Inquiry
BABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 NGF Mouse TNF Mouse Inquiry
FABVC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc NGF Human TNF Human Inquiry
FABVC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc NGF Mouse TNF Mouse Inquiry
SCDBC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 NGF Human TNF Human Inquiry
SCDBC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 NGF Mouse TNF Mouse Inquiry
BSDBC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 NGF Human TNF Human Inquiry
BSDBC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 NGF Mouse TNF Mouse Inquiry
SCDBF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc NGF Human TNF Human Inquiry
SCDBF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc NGF Mouse TNF Mouse Inquiry
BSFVF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc NGF Human TNF Human Inquiry
BSFVF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc NGF Mouse TNF Mouse Inquiry
BSDBF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc NGF Human TNF Human Inquiry
BSDBF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc NGF Mouse TNF Mouse Inquiry
BSTF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv NGF Mouse TNF Mouse Inquiry
BSTF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv NGF Mouse TNF Mouse Inquiry
BSCFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc NGF Mouse TNF Mouse Inquiry
BSCFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc NGF Mouse TNF Mouse Inquiry
MNAB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody NGF Mouse TNF Mouse Inquiry
MNAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody NGF Mouse TNF Mouse Inquiry
BSFC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 NGF Mouse TNF Mouse Inquiry
BSFC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 NGF Mouse TNF Mouse Inquiry
BSCC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL NGF Mouse TNF Mouse Inquiry
BSCC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL NGF Mouse TNF Mouse Inquiry
BIBD-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Mouse TNF Mouse Inquiry
BIBD-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Mouse TNF Mouse Inquiry
FABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Human TNF Human Inquiry
FABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Mouse TNF Mouse Inquiry
MiniB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Human TNF Human Inquiry
MiniB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Mouse TNF Mouse Inquiry
SCDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Human TNF Human Inquiry
FABIG-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Human TNF Human Inquiry
TRIB-H346 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Human TNF Human Inquiry
BSIG-H344 Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Human TNF Human Inquiry
CROSSAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab NGF Human TNF Human Inquiry
IGFV-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Human TNF Human Inquiry
BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Human TNF Human Inquiry
BSFAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Human TNF Human Inquiry
BSFV-H343 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Human TNF Human Inquiry
SCDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Mouse TNF Mouse Inquiry
FABIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Mouse TNF Mouse Inquiry
TRIB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Mouse TNF Mouse Inquiry
BSIG-182 Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Mouse TNF Mouse Inquiry
IGFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Mouse TNF Mouse Inquiry
BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Mouse TNF Mouse Inquiry
BSFAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Mouse TNF Mouse Inquiry
BSFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Mouse TNF Mouse Inquiry

Background

Fig 1. NGF-related upstream and downstream pathways. (Mufson, et al., 2019)Fig.1 NGF-related upstream and downstream pathways.1

Nerve Growth Factor (NGF) serves as a neurotrophic factor that is required for neuron growth, maintenance, and survival. It belongs to the neurotrophin family and plays a critical role in the development and preservation of the nervous system. NGF binds to two kinds of receptors on neuronal cells: TrkA (tropomyosin receptor kinase A), which has a high affinity, and p75NTR, which has a low affinity. Binding to TrkA initiates a signaling cascade that promotes neuronal survival and differentiation, while interaction with p75NTR can lead to apoptosis under certain conditions. NGF's functional applications are diverse, ranging from its use in research to understand neuronal development and neurodegeneration to potential therapeutic uses. Clinically, NGF holds promise for treating neurodegenerative diseases such as Alzheimer's disease, peripheral neuropathies, and certain injuries that affect the nervous system. Its ability to support neuron survival and encourage nerve regeneration makes it a valuable molecule in neuroscience research and therapeutic design.

Reference

  1. Mufson, Elliott J, et al. “Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.” Frontiers in neuroscience vol. 13 533. 1 Jul. 2019.
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