Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG(L)-scFv) (IGLFV-182)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-NGF antibody are fused to the C terminus of an anti-TNF IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

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Specifications

Targets

NGF & TNF

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG(L)-scFv) (CAT#: IGLFV-182)

Specifications

Targets

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