Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) (BSFC-H346)

Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH3) contains two chains. The anti-NGF scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-TNF scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Osteoarthritis therapy.

Datasheet INQUIRY

Specifications

Targets

NGF & TNF

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis

Targets

Target 1

NGF

Gene ID

4803

UniProt ID

P01138

Alternative Names

nerve growth factor; NGF; NGFB; HSAN5; Beta-NGF; beta-nerve growth factor

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) (BSFC-H346). Click the button below to contact us or submit your feedback about this product.

Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) (CAT#: BSFC-H346)

Specifications

Targets

Customer Reviews and Q&As