PDGFR1, also known as platelet-derived growth factor receptor beta (PDGFRβ) in human, encoded by PDGFRB gene, is a cell surface tyrosine kinase receptor and belongs to the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. Tyrosine-protein kinase acts as cell-surface functional receptor for homodimeric (PDGFB and PDGFD) and for heterodimers (PDGFA and PDGFB). Activation of the receptor leads to activation of downstream signaling pathways, which is crucial in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Additionally, the kinase receptor promotes proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells in the development of blood vessel. VEGFA (Vascular endothelial growth factor A), also known as VPF, VEGF or MVCD1, is the most potent growth factor for endothelial cells and belongs to the PDGF/VEGF growth factor family. In humans, it is encoded by the VEGFA gene localizing at the chromosome 6p21.1. VEGF-A, as well as VEGF-C, and -D are found in the lung. During the embryonic and pseudoglandular stages, it is expressed in epithelial and mesenchymal compartments, then becoming more restricted to the epithelium as development process. VEGFA encodes a heparin-binding protein existing as a disulfide-linked homodimer. This growth factor is involved in inducing proliferation and migration of vascular endothelial cells. It is essential for physiological and pathological angiogenesis and considered as a powerful vascular permeability-enhancing agent.