Home > Products > HER2 & VEGF > Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv)

Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv)  (IGFV-168)

Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously and inhibit cell proliferation. It is designed for the research of Colorectal cancer; Breast cancer; Lung cancer; Renal cell cancer (RCC); Glioma cancer; Glioblastoma; Ovarian cancer therapy.

Datasheet
Specifications
Targets
HER2 & VEGF
Type
IgG-scFv
Species Reactivity
Human
Target 1
HER2
Host Animal 1
Mouse
Target 2
VEGF
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Breast cancer; Lung cancer; Renal cell cancer (RCC); Glioma cancer; Glioblastoma; Ovarian cancer
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Target 2
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
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