Home > Products > PDGFR1 & VEGF > Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig)

Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig)  (FVTIG-H349)

Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-PDGFR1 scFv is fused to the CH1 domain of a heavy chain and another anti-VEGF scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two antigens simultaneously. It is designed for the research of Neovascular ocular disorders; Cancers therapy.

Specifications
Targets
PDGFR1 & VEGF
Type
Appended IgGs
Species Reactivity
Human
Target 1
PDGFR1
Host Animal 1
Human
Target 2
VEGF
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Neovascular ocular disorders; Cancers
Targets
Target 1
PDGFR1
Gene ID
UniProt ID
Alternative Names
IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRβ; platelet-derived growth factor receptor beta; PDGFRB
Target 2
VEGF
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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