Anti-ABCG8 Aptamer SELEX Service(Cat#: CTApt-2318)
This is an aptamer development services to screening aptamers binds to the ABCG8 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ABCG8 |
| Alternative Names |
ATP Binding Cassette Subfamily G Member 8; ATP-Binding Cassette, Sub-Family G (WHITE), Member 8; ATP-Binding Cassette Sub-Family G Member 8; Sterolin 2; GBD4; ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (Sterolin 2) ; Gallbladder Disease 4; Sterolin-2; EC 7.6.2.- ; STSL1; ABCG8; STSL |
| Gene ID |
64241 |
| UniProt ID |
Q9H221 |
| Target Overview |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
