Anti-ABL1 aptamer(Cat#: CTApt-2017)
This product is an aptamer which binds to the ABL1 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ABL1 |
| Alternative Names |
ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase; JTK7; P150; V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1; C-Abl Oncogene 1, Receptor Tyrosine Kinase; Abelson Tyrosine-Protein Kinase 1; Tyrosine-Protein Kinase ABL1; Proto-Oncogene C-Abl; EC 2.7.10.2; C-ABL; ABL; Truncated ABL Protooncogene 1 Nonreceptor Tyrosine Kinase; Abelson Murine Leukemia Viral Oncogene Homolog 1; ABL Protooncogene 1 Nonreceptor Tyrosine Kinase; C-Abl Oncogene 1, Non-Receptor Tyrosine Kinase; Proto-Oncogene Tyrosine-Protein Kinase ABL1; Bcr/C-Abl Oncogene Protein; EC 2.7.10; BCR-ABL; Bcr/Abl; CHDSKM; C-ABL1; V-Abl; ABL1 |
| Gene ID |
25 |
| UniProt ID |
P00519 |
| Target Overview |
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
