Anti-ACE Aptamer SELEX Service(Cat#: CTApt-944)
This is an aptamer development services to screening aptamers binds to the ACE with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ACE |
| Alternative Names |
Angiotensin I Converting Enzyme; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1; Angiotensin-Converting Enzyme; Dipeptidyl Carboxypeptidase I; CD143 Antigen; Kininase II; CD143; ACE1; DCP1; DCP; Angiotensin Converting Enzyme, Somatic Isoform; Dipeptidyl Carboxypeptidase 1; Peptidyl-Dipeptidase A; Carboxycathepsin; Peptidase P; EC 3.4.15.1; EC 3.2.1.- ; ACE |
| Gene ID |
1636 |
| UniProt ID |
P12821 |
| Target Overview |
This gene encodes an enzyme involved in in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. ACE also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored proteins in testes. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
