Anti-ACMSD Aptamer(Cat#: CTApt-1376)
This product is an aptamer which binds to the ACMSD with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ACMSD |
| Alternative Names |
Aminocarboxymuconate Semialdehyde Decarboxylase; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; Picolinate Carboxylase; EC 4.1.1.45; ACMSD |
| Gene ID |
130013 |
| UniProt ID |
Q8TDX5 |
| Target Overview |
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
