Anti-ACVR1 Aptamer SELEX Service(Cat#: CTApt-992)
This is an aptamer development services to screening aptamers binds to the ACVR1 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ACVR1 |
| Alternative Names |
Activin A Receptor Type 1; SKR1; Serine/Threonine-Protein Kinase Receptor R1; TGF-B Superfamily Receptor Type I; Activin Receptor-Like Kinase 2; Activin A Receptor, Type I; Activin Receptor Type-1; Activin Receptor Type I; EC 2.7.11.30; ACVRLK2; ACVR1A; ALK2; Activin A Receptor, Type II-Like Kinase 2; Hydroxyalkyl-Protein Kinase; EC 2.7.11; ACTR-I; ACTRI; ACVR1; ALK-2; TSR-I; TSRI; FOP |
| Gene ID |
90 |
| UniProt ID |
Q04771 |
| Target Overview |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
