Anti-AGR2 Aptamer SELEX Service(Cat#: CTApt-1077)
This is an aptamer development services to screening aptamers binds to the AGR2 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AGR2 |
| Alternative Names |
Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HAG-2; AG2; Protein Disulfide Isomerase Family A, Member 17; Secreted Cement Gland Protein XAG-2 Homolog; Anterior Gradient Protein 2 Homolog; PDIA17; XAG-2; AG-2; HPC8; Anterior Gradient 2 Homolog (Xenopus Laevis) ; Epididymis Secretory Protein Li 116; Secreted Cement Gland Homolog; Anterior Gradient Homolog 2; HEL-S-116; GOB-4; AGR2 |
| Gene ID |
10551 |
| UniProt ID |
O95994 |
| Target Overview |
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
