Anti-AGTR2 Aptamer SELEX Service(Cat#: CTApt-1083)
This is an aptamer development services to screening aptamers binds to the AGTR2 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AGTR2 |
| Alternative Names |
Angiotensin II Receptor Type 2; AT2; Type-2 Angiotensin II Receptor; Angiotensin II Type-2 Receptor; MRX88; Angiotensin Receptor 2; ATGR2; AGTR2 |
| Gene ID |
186 |
| UniProt ID |
P50052 |
| Target Overview |
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and SARS-CoV-2 infection result in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors which triggers serious inflammatory lesions, primarily in the lungs, an effect mediated by angiotensin II derivatives. However, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of acute respiratory distress syndrome (ARDS), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
