Anti-ALK Aptamer SELEX Service(Cat#: CTApt-695)
This is an aptamer development services to screening aptamers binds to the ALK with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ALK |
| Alternative Names |
ALK Receptor Tyrosine Kinase; Anaplastic Lymphoma Receptor Tyrosine Kinase; ALK Tyrosine Kinase Receptor; CD246 Antigen; EC 2.7.10.1; CD246; Anaplastic Lymphoma Kinase (Ki-1); Mutant Anaplastic Lymphoma Kinase; Anaplastic Lymphoma Kinase; NBLST3; ALK |
| Gene ID |
238 |
| UniProt ID |
Q9UM73 |
| Target Overview |
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
