Anti-ALOXE3 Aptamer SELEX Service(Cat#: CTApt-1150)
This is an aptamer development services to screening aptamers binds to the ALOXE3 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ALOXE3 |
| Alternative Names |
Arachidonate Lipoxygenase 3; Hydroperoxy Icosatetraenoate Dehydratase; Hydroperoxy Icosatetraenoate Isomerase; Hydroperoxide Isomerase ALOXE3; Hydroperoxy Dehydratase ALOXE3; Epidermis-Type Lipoxygenase 3; Epidermal Lipoxygenase-3; Epidermal LOX-3; E-LOX-3; ELOX-3; E-LOX; ELOX3; Hydroperoxide Isomerase; Epidermal Lipoxygenase; EC 4.2.1.152; EC 5.4.4.7; ALOXE3; ARCI3 |
| Gene ID |
59344 |
| UniProt ID |
Q9BYJ1 |
| Target Overview |
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
